NEST COP Pre-filled Syringes are in high demand in the pharmaceutical market due to their small size, portability, accurate drug dosage provision, and low risk of contamination. They are widely used as a container of high-value products such as biologics, biochemical products, anti-thrombotic drugs, and beauty products.
Serving as alternatives to borosilicate glass, cyclic olefin polymers (COP) offers a high degree of flexibility in design. Its high crack-resistance also reduces logistics and transportation costs. In terms of other physical and chemical properties, COP exhibits high transparency,
rigidity, heat resistance, low refractive index, low protein adsorption, and is free from heavy metals and tungsten. Compatibility tests with
pharmaceuticals indicate no delamination. And it can be manufactured with low or no silicone content, addressing the limitations of glass
pre-filled syringes.
Application
• Container for biological agents (such as GLP-1, hormones, monoclonal antibodies)
• Ophthalmic applications
• Emergency drugs
• Vaccines
• Medical aesthetic drugs
• Compatible with automatic injectors
Plunger
• Design Compatibility
• Compliant with ISO 11040 standard
• Material: Polycarbonate (PC)
• Fit high-speed sealing production line
• Compatible with plunger chamber
• Customizable shape, available in standard or custom colors
• Manufactured in a class 10,000 cleanroom
• Sterilized by electron beam
Order information for Finger Flanger
(Double-bagged, non-sterile)
| Specifications | /Pack | /Case | Cat.No. | Matching Accessories |
| 1.0 mL | 5000 | 5000 | 205591 | Plunger205512/Finger Flang205592 |
| 1.0mL Slender | 5000 | 5000 | 205571 | Plunger205502/Finger Flang205572 |
| 2.25 mL | 5000 | 5000 | 205581 | Plunger205522/Finger Flang205582 |
Finger Flange
• Polypropylene (PP)
• Compatible with ISO 11040 compliant check valves with injection flange or beveled flange
• Manufactured in a Class 10,000 cleanroom
• Customizable design
• Sterilized by electron beam
Order information for Finger Flanger
(Double-bagged, non-sterile)
| Specifications | /Pack | /Case | Cat.No. | Matching Accessories |
| 1.0 mL | 10000 | 10000 | 205592 | Plunger205512/Finger Flang205591 |
| 1.0mL Slender | 10000 | 10000 | 205572 | Plunger205502/Finger Flang205571 |
| 2.25 mL | 10000 | 10000 | 205582 | Plunger205522/Finger Flang205581 |
Key Features
• Excellent drug stability, low protein adsorption, and barrier properties against water vapor and oxygen permeation.
• Eliminates the need for drug reconstitution before injection, reducing the risk of drug contamination.
• Accurate drug composition, avoiding changes in drug proportions during on-site drug preparation.
• Luer Connector, in line with the International Standard, is included to ensure secure connections and achieve excellent sealing performance. This reduces drug leakage and prevents the risk of needle rotation and popping during injection.
• COP offers a high degree of design flexibility and allows for greater customization.
• Compatible with various sterilization methods, such as ethylene oxide sterilization and steam sterilization.
• Complies with ISO 9001, ISO 15378, YBB, and USP Class VI standards.
Advantages of COP material compared to other materials.
| Features | COP | Glass | PP |
| Gas permeability (O2, N2, CO2) | M | G | M |
| Water vapor permeability | G | G | M |
| Transparency after steam sterilization | G | G | P |
| Transparency after EP sterilization | G | G | P |
| Transparency after gamma ray sterilization | G | G | P |
| Drug pH change | G | P | G |
| Brittleness | G | P | G |
| Precision Molding/processing type | G | P | G |
| Waste characteristics/combustion characteristics | G | P | G |
| High purity | G | G | M |
Rubber Stopper and Luer Cap
Made of butyl rubber bromide and compliant with European Pharmacopoeia, United States Pharmacopoeia, and Japanese Pharmacopoeia.
| Product | Material | Rubber Stopper Formulation | Color |
| Rubber Stopper | Butyl Bromide | HS264 | Black |
| Luer Cap | Butyl Bromide | HM174 | Gray |
